The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San Francisco gets in.

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

Kyle Shanahan revealed he spoke with Rivers last week when the signal-caller was chatting with San Francisco assistant coach Gus Bradley.

The 49ers will look to carry that momentum into Week 16 when they hit the road for a matchup against the Indianapolis Colts. San Francisco is set to face veteran quarterback Philip Rivers, who recently came out of retirement to replace Daniel Jones after the Colts' starter suffered a season-ending Achilles injury.

San Francisco 49ers stars Christian McCaffrey and Kyle Juszczyk both sit atop their positions in Pro Bowl fan voting.

The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games.

Although nothing seems to have gone well for the 49ers this season, San Francisco still is in good shape to make a run in the 2025 NFL playoffs.

There are four teams on a bye in Week 14, the final bye week of the season. The 49ers, Giants, Panthers and Patriots are on a bye this week. More: NFL Week 14 picks straight up and against spread: Packers or Bears in NFC North showdown?

The San Francisco 49ers are a National Football League team that plays in the NFC West division. The 49ers have won five Super Bowl titles over the course of their history.

The San Francisco 49ers have signed wide receiver Javon Baker to the practice squad, adding depth to their receiving corps. To make room, the team released kicker Matt Gay and quarterback Adrian Martinez from the practice squad. ESPN's Jeremy Fowler first reported the news of...