The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut ...

A study published in the journal Protein & Cell details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid ...

The VDR is a member of the steroid/hormone nuclear receptor superfamily that includes 48 ligand-activated transcription factors. [3] These factors bind to conserved elements in the promoters of genes ...

(A) Female and male body weight change over the course of 16 weeks for FXR hep flox/flox and FXR hep-/- (B) Female and male liver-to-body weight ratios; (C) H&E stained liver sections (n=3–6); (D) ...

For the first time, a team of experts from the Technical University of Munich (TUM), RWTH Aachen University, and the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) has demonstrated the ...

Toxic accumulation of lipids in the heart is a major contributor to the cardiac remodelling and dysfunction that occurs in individuals with diabetic cardiomyopathy. A study now shows that activation ...

Cardiovascular diseases (CVD) remain a major cause of death, whose prevention of modifiable risk factors can lower the incidence of ischemic events 1,2. Increased morbidity and mortality by CVD are ...