Researchers developed linafexor, a short-acting FXR agonist that mimics bile acid rhythms. In clinical trials, the drug ...

Bile acids are amphipathic steroid molecules synthesised from cholesterol in the liver and secreted into the intestine where they facilitate lipid digestion and absorption. Primary bile acids are ...

Metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis ...

Liver is the major organ for metabolism of sulfur amino acids (methionine, cysteine, taurine) and expresses high levels of sulfur amino acid synthesis and metabolising enzymes. Dietary intake, ...

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking ...

In a study published in Nature on January 28, a research team led by Eric H. Xu (Xu Huaqiang) from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, along with Ma Xiong from ...

Studies in mice reveal a new target for potentially treating and preventing life-threatening cardiovascular complications in the millions of patients with sleep apnea worldwide.

Cholic acid (3α,7α,12α-trihydroxy-5β-cholan-24-oic acid) is a bile acid produced in the liver from cholesterol 1. Reports of the identification of cholic acid began to appear in the late 1800s; in ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...