After it fills with cargo, the pit pinches off to form a clathrin-coated, membrane-bound vesicle inside the cell, which then proceeds to its proper destination. In cultured cells, hundreds of these ...

Clathrin-mediated endocytosis (CME) is the principal pathway by which eukaryotic cells internalise receptors, nutrients and signalling molecules from the plasma membrane. The process begins with ...

Researchers have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study could inform ...

Our model proposes that in synapses, ATM protein localizes predominately in presynaptic terminals, while ATR localizes on both side of synapse. ATM binds exclusively to VGLUT1+ vesicles, while ATR ...

Cells have a clever way to transport cargos like growth factors across the cell membrane and into the cell. It is called clathrin-mediated endocytosis. Molecules of the protein clathrin gather on the ...

Cells have a clever way called clathrin-mediated endocytosis to transport cargos like growth factors across the cell membrane and into the cell. Researchers used a sophisticated fluorescence ...