There's an eclectic group of contests to make Week 10 college football bets on, with old-school rivalries and new-age ones as well. No. 1 Ohio State vs. Penn State has the Buckeyes favored by 19.5 points,

The college football Week 10 schedule is headlined on Saturday with Oklahoma at Tennessee. See the college football schedule for Week 10 here.

Lane Kiffin and Co. square off against the Gamecocks in Week 10, stage set for a critical SEC clash for the Rebels.

The model is also backing USC (-4.5) to cover the spread on the road against Nebraska, while the Under (55.5) hits 66% of the time in Cincinnati vs. Utah. Before locking in your Week 10 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model.

College football odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 1:05 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub. Game time: 8 p.m. ET Game date: Oct. 28 Game time: 7:30 p.m. ET Game date: Nov. 1

Who could've thought that an early-November game between Vanderbilt and Texas could be do-or-die for both teams - and slanted heavily towards a "can't-lose" for the Longhorns to boot? That's the situation over in Austin,

Week 10 college football odds, best bets: Top Friday college football picks, betting predictions for Oct. 31

College football best bets for Week 10 afternoon games, including Georgia vs. Florida, Texas Tech vs. Kansas State, and Notre Dame vs. Boston College.

Coming out of the latest Saturday of action, let’s take a look at the updated ESPN top 25 college football rankings as we look ahead to the Week 10 games. We di