Figure 5: Downregulation of PC-1 in Tsc1 mutant kidneys contributes to cyst formation. Figure 6: Proposed model of cross regulation of the PKD and TSC genes. In sum, our data uncover a novel, ...

March is National Kidney Month, which makes this a good time to learn more about the difference between two kidney disorders — kidney cysts and polycystic kidney disease. Your kidneys are situated in ...

Tuberous sclerosis complex (TSC) afflicts as many as two million people around the world, affecting multiple organs, including lungs, brain, skin, and kidneys. In about 80 percent of cases, it causes ...

Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic renal disease, primarily caused by germline mutation of PKD1 or PKD2, leading to end-stage renal disease. The Hippo ...

Birt-Hogg-Dubé syndrome (BHDS) is a genetic disorder that increases the risk of developing benign skin cancers, polycystic kidney disease (PKD), lung cysts, and many types of kidney cancers. PKD is ...

Cysts can form in the kidney for many reasons, and most such cysts are benign (non-cancerous). However, in some instances a cyst may become enlarged to the point that it causes pain, obstructs the ...

A kidney cyst is a swollen, round, fluid-filled sac that develops on one or both of the kidneys. These cysts can be associated with serious conditions that affect the kidney’s ability to function, but ...

Mayo Clinic researchers have developed a promising gene-editing therapy that directly corrects a genetic mutation responsible for autosomal dominant polycystic kidney disease (ADPKD), the most common ...

A 46-year-old man who recently moved to the area was referred to the nephrology clinic for kidney cysts. He was found to have multiple cysts in the left kidney at age 27 for which he was referred to ...

Melatonin, a hormone commonly associated with sleep-wake regulation, has been found to reduce cysts in fruit flies, according to researchers. It's a finding that may affect the way we treat some ...