In mammals, fatty acids are essential components that can be synthesized de novo within cells or supplied from the diet. De novo syntheses are carried out by a large multidomain enzyme, FASN 1. During ...

Here we used single-particle analysis cryo-electron microscopy (cryo-EM) to determine structures of full-length human FASN (hFASN) with the cofactor NADPH in various conformational states, and with ...