The US Food and Drug Administration (FDA) on Thursday released draft guidance to help sponsors understand the evidence necessary to demonstrate the effectiveness of new drugs, including biologics, or ...

Although gout is no longer caricatured as a comical disease caused by high living and swilling port wine, it is still regarded as an affliction almost exclusively of adult men, many of whom like to ...

Berkeley -- As the cost of sequencing a single human genome drops rapidly, with one company predicting a price of $100 per person in five years, soon the only reason not to look at your "personal ...

A rare genetic defect that affects the so-called ALG2 gene can cause serious metabolic diseases in humans. Until now, its rareness and complexity made it difficult to study this congenital ...

Sucrase-isomaltase (SI) is an intestinal enzyme critical for the digestion of dietary carbohydrates, particularly sucrose and starch. Previous studies from the Gastrointestinal Genetics team at CIC ...

The findings, published in Nature Metabolism, open a new path toward future treatments for severe mitochondrial diseases that currently have no cure Nucleotide synthesis—the production of the basic ...

In one type of a rare, inherited genetic disorder that affects control of body movement, scientists have found a mutation in an enzyme that impairs communication between neurons and what should be the ...

Sucrase-isomaltase (SI) is an intestinal enzyme critical for the digestion of dietary carbohydrates, particularly sucrose and starch. Previous studies from the Gastrointestinal Genetics team at CIC ...

Liver enzymes can fluctuate due to factors like hormonal changes or reactions to medications. Fluctuations are often temporary, but long-term changes may indicate a condition that requires medical ...

Mitochondrial diseases are severe, often untreatable, and they leave human cells unable to grow normally without outside help. A new study published in Nature Metabolism now shows that a single gene ...