Northwestern Medicine scientists have, for the first time, described the underlying mechanisms that regulate how cells ...

Insulin is produced by pancreatic β-cells and acts as a major anabolic hormone in the control of glucose, lipid, and protein homeostasis 1,2. At the cellular level, these effects are mediated by the ...

Kinases constitute a family of more than 500 enzymes and play critical roles in cellular signaling, both in normal and diseased cells. As a result, kinases continue to be key drug targets, especially ...

Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...

Neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis) are major health threats for the aging population and their prevalences continue to ...

Sjögren’s disease (SjD) is a chronic, multisystem autoimmune disorder characterised by lymphocytic infiltration of exocrine ...