A team of researchers has found a quicker and more efficient way to create nucleoside analogs, a type of small molecule that can be used in treatments for everything from cancer to viral diseases.

The discovery of ArcS, which can utilize a nucleoside as a minimum substrate, provides new insights into the synthesis of precursor molecules for these modified nucleosides. The results of this ...

DNA, often called the blueprint of life, is built from four chemical building blocks known as deoxy-nucleoside triphosphates (dNTPs)—dATP, dTTP, dGTP, and dCTP. Cells constantly need these molecules ...

Nucleoside derivatives have important therapeutic activity in chronic lymphocytic leukaemia (CLL). Experimental evidence indicates that in CLL cells most of these drugs induce apoptosis ex vivo, ...

Combination antiretroviral therapy (ART) has transformed HIV-1 infection into a chronic condition with near-normal life expectancy. For more than two decades, the standard regimen has been a ...

Acute lymphoblastic leukemia is the most common type of childhood leukemia, with about 5,000 children diagnosed in the U.S. each year. Now researchers have synthesized a nonnatural deoxynucleoside ...

Obeldesivir (GS-5245), a novel investigational small molecule oral antiviral, represents a new tool in the ongoing effort to prepare for future pandemics. Obeldesivir (GS-5245), a novel ...

Regimens containing three nucleoside reverse-transcriptase inhibitors offer an alternative to regimens containing nonnucleoside reverse-transcriptase inhibitors or protease inhibitors for the initial ...

A single enzyme that can generate all four nucleoside triphosphates, the building blocks of ribonucleic acid (RNA), has been identified by researchers at the Institute of Science Tokyo. The study was ...

Nucleotides are the phosphate esters of nucleoside and are the building blocks of DNA and RNA. All nucleotides have three components: a nitrogen-containing heterocyclic base, a pentose sugar, and a ...

Pathogen recognition is based on the presence of Toll-like receptors (TLRs), which detect pathogen-associated molecular patterns (PAMPs) to coordinate the immune cascade. These receptors are encoded ...