Phys.org

Phosphorylation enables tau protein to form reversible droplets, offering insights into early Alzheimer's

In a study published in the Journal of the American Chemical Society, scientists explore how a brain protein called tau changes its behavior when a small chemical group called a phosphate attaches to ...
Nature

Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4

Piwi-interacting RNAs (piRNAs) are genomically encoded small RNAs that engage Piwi Argonaute proteins to direct mRNA surveillance and transposon silencing. Despite advances in understanding piRNA ...
Nature

Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

Neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis) are major health threats for the aging population and their prevalences continue to ...
Science Daily

Phosphorylation and dephosphorylation enzyme groups regulate sleep and wakefulness in mammals

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance ...
EurekAlert!

Scientists discover the ‘ticking’ mechanism driving nature’s simplest circadian clock

Aichi, Japan--Researchers from the Institute for Molecular Science (IMS)/SOKENDAI and Kyushu University have uncovered the molecular mechanism that drives the "ticking" of the circadian clock in ...