We describe two siblings from a consanguineous family with autosomal recessive Fanconi's syndrome and hypophosphatemic rickets. Genetic analysis revealed a homozygous in-frame duplication of 21 bp in ...

In renal Fanconi's syndrome, dysfunction in proximal tubular cells leads to renal losses of water, electrolytes, and low-molecular-weight nutrients. For most types of isolated Fanconi's syndrome, the ...

Every day our kidneys tackle the daunting task of continuously cleaning our blood to prevent waste, salt and excess fluid from building up inside our bodies. To achieve this, the kidneys' ...

Transform your drug development pipeline with Newcells’ Renal Proximal Tubule Cells Model eBook. This eBook provides insight into the science behind aProximate ™, an innovative proximal tubule cell ...

Excessive phosphate loading within the proximal tubular lumen has been proposed as a key mechanism driving progression of ...