To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation.

It has been over a decade since super-resolution microscopy was awarded the 2014 Nobel Prize in Chemistry, and after tremendous advancements over the years, it is on its way to becoming a standard ...

Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

A recent study published in the journal Cell Reports Physical Science introduced a novel super-resolution imaging technique called resonant multi-focal scanning microscopy (RSM). The objective was to ...

There is a growing demand for non-invasive insights into the complex three-dimensional subcellular dynamics within living tissues on the frontier of biological research. To achieve simultaneous ...

Existing super-resolution techniques still face considerable challenges in complex deep tissue environments. For example, Stimulated Emission Depletion (STED) microscopy relies on a doughnut-shaped ...

Next, the images are improved further using advanced computer algorithms. These included techniques to reduce "noise" (unwanted blurry spots in images), correct for tiny shifts or drifts in the ...

The Advanced Light Microscopy and Innovation Lab (ALMIL) supports MSK researchers by advancing the use of cutting-edge imaging techniques to study complex biological systems. As a specialized hub, ...

Every plant, animal, and person is a rich microcosm of tiny, specialized cells. These cells are worlds unto themselves, each with their own unique parts and processes that elude the naked eye. Being ...

Synaptic dysfunction heralds cognitive and behavioral decline in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. Oligomers of Aβ, tau, and ɑ-synuclein may be to blame, but ...

Recent advances in optical physics have redefined the classical boundaries imposed by diffraction. Super-resolution imaging techniques, which once adhered strictly to the Rayleigh criterion, now ...