Why does pyroptosis take place? Pyroptosis is a form of programmed cell death that occurs during intracellular pathogen infection, as part of the body's antimicrobial response. Cell-surface receptors ...

Identification of Pancreatic Cancer Germline Risk Variants With Effects That Are Modified by Smoking A sum of 921 samples were collected from three independent data sets. We obtained ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

Mitochondria, the “powerhouses of the cell,” are vital cellular organelles that govern energy metabolism, maintain redox homeostasis, synthesize biomacromolecules, and initiate and transmit cell death ...

Pyroptosis is a unique immunogenic form of cell death dependent on inflammasome activation, provoked when pattern recognition receptors (PRRs) sense microbial infection or cellular stress. Caspase-1, ...

Inflammatory responses are characterized by the release of endogenous DAMPs, also known as alarmins. During non-apoptotic programmed or regulated cell death, such as pyroptosis and necroptosis, HMGB1 ...

Neurogenic bladder is a disease involving inflammation and fibrosis of the bladder. Fibrosis has been linked to the type of programmed cell death known as pyroptosis, which in turn has been linked to ...

Aria Pharmaceuticals Inc. has synthesized compounds acting as caspase-1 (IL-1β-converting enzyme) and pyroptosis inhibitors reported to be useful for the treatment of alopecia, autoimmune hemolytic ...