Must-win AFC North and NFC South showdowns? No. 1 seeds on the line? We have picks, predictions, stats and what's at stake for every Week 18 game.

See Rams vs. Panthers NFL Wild Card odds, predictions, and betting analysis, including spreads, over/unders, and key factors to watch.

But the teams feel strangely closer than the seeds suggest. The Patriots played the NFL’s easiest schedule, while it’s widely accepted that Chargers quarterback Justin Herbert is capable of MVP play and the team overcame some wicked injuries.

The San Francisco 49ers travel to take on the Philadelphia Eagles on Sunday, setting up a great coaching matchup between 49ers coach Kyle Shanahan and Eagles defensive coordinator Vic Fangio. Plus, we'll look at an Eagles offense that is still seeking a sense of sustained rhythm, but also a unit featuring explosive playmakers.